The basic science of tendinopathy.

Patellar tendinopathy: some aspects of basic science and clinical management.

Tendon injuries account for a substantial proportion of overuse injuries in sports. Despite the morbidity associated with patellar tendinopathy in athletes, management is far from scientifically based. After highlighting some aspects of clinically relevant basic science, we aim to (a) review studies of patellar tendon pathology that explain why the condition can become chronic, (b) summarise th...

PRP Treatment Efficacy for Tendinopathy: A Review of Basic Science Studies

Platelet-Rich Plasma (PRP) has been widely used in orthopaedic surgery and sport medicine to treat tendon injuries. However, the efficacy of PRP treatment for tendinopathy is controversial. This paper focuses on reviewing the basic science studies on PRP performed under well-controlled conditions. Both in vitro and in vivo studies describe PRP's anabolic and anti-inflammatory effects on tendons...

Achilles tendinopathy: some aspects of basic science and clinical management.

Achilles tendinopathy is prevalent and potentially incapacitating in athletes involved in running sports. It is a degenerative, not an inflammatory, condition. Most patients respond to conservative measures if the condition is recognised early. Surgery usually involves removal of adhesions and degenerated areas and decompression of the tendon by tenotomy or measures that influence the local cir...

Tendinopathy and its treatment with platelet-rich plasma (PRP).

This article has two goals. First, it reviews studies on tendinopathy in the literature while highlighting the following points: a) tendinopathy refers to a spectrum of tendon disorders with multiple facets of "tissue phenotypes," and b) mechanical loading is a major factor that contributes to the development of tendinopathy by inducing the aberrant differentiation of tendon stem/progenitor cel...

Achilles Tendinopathy: From the Basic Science to the Clinic

Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach

Chronic tendinopathies represent a major problem in the clinical practice of sports orthopaedic surgeons, sports doctors and other health professionals involved in the treatment of athletes and patients that perform repetitive actions. The lack of consensus relative to the diagnostic tools and treatment modalities represents a management dilemma for these professionals. With this review, the pu...